144
EQUINE VETERINARY EDUCATION / AE / MARCH 2016
Acknowledgements
The authors would like to acknowledge all the practitioners that participated in this study including Drs H. Von Bluecher, J. Dowd, R. Carpenter, S. Meyer, D. Hunkin, T. Brokken, S. Schmidt, A. Troncatty, A. Yocoub, J. Lorbiecki and G. Blodgett as well as D. McKemie, S. Yim and S. Mouton from the K.L. Maddy Equine Analytical Chemistry Laboratory.
Authorship
H. Knych and R. Arthur contributed to study design, study execution, data analysis and interpretation and preparation of the manuscript. J. Blea and L. Overly contributed to study design and study execution. W. McIlwraith contributed to study design, data analysis and interpretation. All authors gave their final approval of the manuscript.
Manufacturers' addresses
1Boehringer Ingelheim Vetmedica, St Louis, Missouri, USA. 2Bristol-Meyers Squibb Company, Princeton, New Jersey, USA. 3Zoetis, Florham Park, New Jersey, USA. 4Merck & Co, Inc, Whitehouse Stations, New Jersey, USA. 5American Regent, Inc, Shirley, New York, USA. 6Kendall/Tyco Healthcare, Mansfield, Massachusetts, USA. 7Phenix Research Products, Chandler, North Carolina, USA. 8Arthrodynamic Technologies Inc, Lexington, Kentucky, USA.
References
Anon(2014) RMTC Position Statement on Corticosteroids. Racing Medication
and Testing
www.rmtcnet.com/
content_education.asp.
ARCI Model Rules, Association of Racing Commissioners International,
http://arcicom.businesscatalyst.com/model-rules—
standards.html.
Autefage, A., Alvinerie, M. and Toutain, P.L. (1986) Synovial fluid and plasma kinetics of methylprednisolone acetate in horses following intra-articular administration of methylprednidolone acetate. Equine Vet. J. 18, 193-198.
Benson, D., Arthur, R.M., Bramlage, L., Colahan, P., Sams, R.A. and Scollay, M. (2014) Determination of a plasma threshold and withdrawal guidance recommendation for isoflupredone administered intra-articularly and subcutaneously as its acetate ester. In: Proceedings of the International Conference of Racing Chemists and Veterinarians, R&WCommunications,Newmarket, UK.
Consortiumhttp://
Ferris, D.J., Frisbie, D.D., McIlwraith, C.W. and Kawcak, C.E. (2011) Current joint therapy usage in equine practice: a survey of veterinarians 2009. Equine Vet. J. 43, 530-535.
Knych, H.K., Fleming, K., VanPelt, S. and Carter, J. (2011) Elimination of triamcinolone acetonide after intraarticular administration to performance horses (abstract). Proc. Am. Ass. Equine Practnrs. 57, 84.
Knych, H.K., Vidal, M.A., Casbeer, H.C. and McKemie D.S. (2013) Pharmacokinetics of triamcinolone acetonide following intramuscular and intra-articular administration to exercised Thoroughbred horses. Equine Vet. J. 45, 715-720.
Knych, H.K., Harrison, L.M., Casbeer, H.C. and McKemie, D.S. (2014) Disposition of methylprednisolone acetate in plasma, urine and synovial fluid following intra-articular administration to exercised Thoroughbred horses. J. Vet. Pharmacol. Ther. 37, 125-132.
Knych, H.K., Harrison, L.M., White, A. and McKemie, D.S. (2015)
Disposition of isoflupredone acetate in plasma, urine and synovial fluid following intra-articular administration to exercised Thoroughbred horses. Drug Test Anal. Epub ahead of print; doi: 10.1002/dta.1834.
Lillich, J.D., Bertone, A.L., Schmall, L.M., Ruggles, A.J. and Sams, R.A. (1996) Plasma, urine and synovial fluid disposition of methylprednisolone acetate and isoflupredone acetate after intra- articular administration in horses. Am. J. Vet. Res. 57, 187-192.
McIlwraith, C.W. (2010) The use of intra-articular corticosteroids in the horse: what is known on a scientific basis?. Equine Vet. J. 42, 563- 571.
Menendez, M.I., Phelps, M.A., Hothem, E.A. and Bertone, A.L. (2012) Pharmacokinetics of methylprednisolone acetate after intra- articular administration and subsequent suppression of endogenous hydrocortisone secretion in exercising horses. Am. J. Vet. Res. 73, 1453-1461.
Menendez, M.I., Phelps, M.A. and Bertone, A.L. (2015) Pharmacokinetics of intra-articular betamethasone sodium phosphate and betamethasone acetate and endogenous hydrocortisone suppression in exercising horses. J. Vet. Pharmacol. Therap. Epub ahead of print; doi: 10.1111/jvp.12229.
Soma, L.R., Uboh, C.E., Luo, Y., Guan, F., Moate, P.J. and Boston, R.C. (2006) Pharmacokinetics of methylprednisolone acetate after intra- articular administration and its effect on endogenous hydrocortisone and cortisone secretion in horses. Am. J. Vet. Res. 67, 654-662.
Soma, L.R., Uboh, C.E., You, Y., Guan, F. and Boston, R.C. (2011) Pharmacokinetics of intra-articular, intravenous and intramuscular administration of triamcinolone acetonide and its effects on endogenous plasma hydrocortisone and cortisone concentrations in horses. Am. J. Vet. Res. 72, 1234-1242.
© 2016 EVJ Ltd
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88
