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remains common in some populations and the use of specific therapeutics is warranted in affected animals. Omeprazole remains the best studied of these with recent work suggesting that lower doses than traditionally used may be efficacious. Conversely, a small subset of the population appear refractory to omeprazole treatment and other therapeutic modalities such as ranitidine and/or specific neutraceutical complexes warrant consideration in selected cases.
Authors’ declaration of interests
One of the authors (BWS) is employed as a consultant by Boehringer Ingelheim, the manufacturers of Pronutrin. The manufacturer’s of Gastrozol have previously sponsored research by one of the authors (BWS). Neither company was involved in the development of this manuscript.
References
Andrews, F., Bernard, W., Byars, D., Cohen, N., Divers, T., MacAllister, C., McGladdery, A., Merritt, M., Murray, J., Orsini, J., Snyder, J. and Vatistas, N. (1999a) Recommendations for the diagnosis and treatment of equine gastric ulcer syndrome (EGUS). Equine Vet. Educ. 11, 262-272.
Andrews, F. and Jenkins, C. (1992) Effect of oral omeprazole on basal and pentagastrin-stimulated gastric secretion in young female horses. Equine Vet. J. 24, 80-83.
Andrews, F.M., Frank, N., Sommardahl, C.S., Buchanan, B.R., Elliott, S.B. and Allen, V.A. (2006) Effects of intravenously administrated omeprazole on gastric juice pH and gastric ulcer scores in adult horses. J. Vet. Intern. Med. 20, 1202-1206.
Andrews, F.M., Sifferman, R.L., Bernard, W., Hughes, F.E., Holste, J.E., Daurio, C.P., Alva, R. and Cox, J.L. (1999b) Efficacy of omeprazole paste in the treatment and prevention of gastric ulcers in horses. Equine Vet. J. 31, Suppl. 29, 81-86.
Begg, L.M. and O’Sullivan, C.B. (2003) The prevalence and distribution of gastric ulceration in 345 racehorses. Aust. Vet. J. 81, 199-201.
Bell, R.J.W., Kingston, J.K., Mogg, T.D. and Perkins, N.R. (2007) The prevalence of gastric ulceration in racehorses in New Zealand. N. Z. Vet. J. 55, 13-18.
Berschneider, H.M., Blikslager, A.T. and Roberts, M.C. (1999) Role of duodenal reflux in nonglandular gastric ulcer disease of the mature horse. Equine Vet. J. 31 Suppl. 29, 24-29.
Bertone, J. (2000) Prevalence of gastric ulcers in elite heavy use western performance horses. Proc. Am. Ass. Equine Practnrs. 46, 256-259.
Birkmann, K., Junge, H.K., Maischberger, E., Wehrli Eser, M. and Schwarzwald, C.C. (2014) Efficacy of omeprazole powder paste or enteric-coated formulation in healing of gastric ulcers in horses. J. Vet. Intern. Med. 28, 925-933.
Campbell-Thompson, M.L. and Merritt, A.M. (1987) Effect of ranitidine on gastric acid secretion in young male horses. Am. J. Vet. Res. 48, 1511-1515.
Cargile, J., Burrow, J. and Kim, I. (2004) Effect of dietary corn oil supplementation on equine gastric fluid acid, sodium, and prostaglandin E2 content before and during pentagastrin infusion. J. Vet. Intern. Med. 18, 545-549.
Cate, R.E., Nielsen, B.D., Spooner, H.S., O’Connor-Robison, C.I. and Schott, H.C., II (2012) Prevalence of gastric ulcers and relationship to other parameters in Standardbred racehorses. Comp. Exerc. Physiol. 8, 47-51.
Clark, C.K., Merritt, A.M., Burrow, J.A. and Steible, C.K. (1996) Effect of aluminium hydroxide/magnesium hydroxide antacid and bismuth subsalicylate on gastric pH in horses. J. Am. Vet. Med. Ass. 208, 1687-1691.
Daurio, C.P., Holste, J.E., Andrews, F.M., Merritt, A.M., Blackford, J.T., Dolz, F. and Thompson, D. (1999) Effect of omeprazole paste on gastric acid secretion in horses. Equine Vet. J. 31 Suppl. 29, 59-62.
Dionne, R., Vrins, A. and Doucet, M. (2003) Gastric ulcers in Standardbred racehorses: prevalence, lesion description, and risk factors. J. Vet. Int. Med. 17, 218-222.
Doucet, M.Y., Vrins, A.A., Dionne, R., Alva, R. and Ericsson, G. (2003) Efficacy of a paste formulation of omeprazole for the treatment of naturally occurring gastric ulcers in training Standardbred racehorses in Canada. Can. Vet. J. 44, 581-585.
Endo, Y., Tsuchiya, T., Sato, F., Murase, H., Omura, T., Korosue, K., Nambo, Y., Ishimaru, M. andWakui, Y. (2012) Efficacy of omeprazole paste in the prevention of gastric ulcers in 2 years old thoroughbreds. J. Vet. Med. Sci. 74, 1079-1081.
Fellenius, E., Berglindh, T., Sachs, G., Olbe, L., Elander, B., Sjostrand, S.-E. and Wallmark, B. (1981) Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase. Nature 290, 159-161.
Habershon-Butcher, J.L., Hallowell, G.D., Bowen, I.M. and Sykes, B.W. (2012) Prevalence and risk factors for ulceration of the gastric glandular mucosa in Thoroughbred racehorses in training in the UK and Australia [abstract]. J. Vet. Intern. Med. 26, 731.
Hammond, C.J., Mason, D.K. andWatkins, K.L. (1986) Gastric ulceration in mature thoroughbred horses. Equine Vet. J. 18, 284-287.
Haven, M.L., Dave, K., Burrow, J.A., Merritt, A.M., Harris, D., Zhang, D. and Hickey, G.J. (1999) Comparison of the antisecretory effects of omeprazole when administered intravenously, as acid-stable granules and as an oral paste in horses. Equine Vet. J. 29, 4-8.
Hellings, I.R. and Larsen, S. (2014) ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses. Acta Vet. Scand. 56, 13.
Hepburn, R. (2011) Gastric ulceration in horses. In Pract. 33, 116-124.
Holbrook, T.C., Simmons, R.D., Payton, M.E. and MacAllister, C.G. (2005) Effect of repeated oral administration of hypertonic electrolyte solution on equine gastric mucosa. Equine Vet. J. 37, 501-504.
Huff, N.K., Auer, A.D., Garza, F., Keowen, M.L., Kearney, M.T., McMullin, R.B. and Andrews, F.M. (2012) Effect of sea buckthorn berries and pulp in a liquid emulsion on gastric ulcer scores and gastric juice pH in horses. J. Vet. Intern. Med. 26, 1186-1191.
Husted, L., Sanchez, L.C., Olsen, S.N., Baptiste, K.E. and Merritt, A.M. (2008) Effect of paddock vs. stall housing on 24 hour gastric pH within the proximal and ventral equine stomach. Equine Vet. J. 40, 337-341.
Jenkins, C.C., Blackford, J.T., Andrews, F., Frazier, D.L., Mattsson, H., Olovsson, S.-G. and Peterson, A. (1992a) Duration of antisecretory effects of oral omeprazole in horses with chronic gastric cannulae. Equine Vet. J. 24, 89-92.
Jenkins, C.C., Frazier, D.D.L., Blackford, J.T.J., Andrews, F.M., Mattsson, H., Olovsson, S.-G. and McCleod, M. (1992b) Pharmacokinetics and antisecretory effects of intravenous omeprazole in horses. Equine Vet. J. 24, 84-88.
Lester, G.D., Smith, R.L. and Robertson, I.D. (2005) Effects of treatment with omeprazole or ranitidine on gastric squamous ulceration in racing Thoroughbreds. J. Am. Vet. Med. Ass. 227, 1636-1639.
Lorenzo-Figueras, M. and Merritt, A. (2002) Effects of exercise on gastric volume and pH in the proximal portion of the stomach of horses. Am. J. Vet. Res. 63, 1481-1487.
Luthersson, N., Nielsen, K.H., Harris, P. and Parkin, T.D.H. (2009a) The prevalence and anatomical distribution of equine gastric ulceration syndrome (EGUS) in 201 horses in Denmark. Equine Vet. J. 41, 619-624.
Luthersson, N., Nielsen, K.H., Harris, P. and Parkin, T.D.H. (2009b) Risk factors associated with equine gastric ulceration syndrome (EGUS) in 201 horses in Denmark. Equine Vet. J. 41, 625-630.
MacAllister, C.G., Sifferman, R.L., McClure, S.R., White, G.W., Vatistas, N.J., Holste, J.E., Ericcson, G.F. and Cox, J.L. (1999) Effects of omeprazole paste on healing of spontaneous gastric ulcers in horses and foals: a field trial. Equine Vet. J., Suppl. 31, 77-80.
Marqués, F.J., Epp, T.,Wilson, D., Ruiz, A.J., Tokateloff, N. and Manning, S. (2011) The prevalence and risk factors of oesophageal and nonglandular gastric lesions in Thoroughbred racehorses in Saskatchewan. Equine Vet. Educ. 23, 249-254.
McClure, S.R., Glickman, L.T. and Glickman, N.W. (1999) Prevalence of gastric ulcers in show horses. J. Am. Vet. Med. Ass. 215, 1130-1133.
McClure, S., Carithers, D. and Gross, S. (2005a) Gastric ulcer development in horses in a simulated show or training environment. J. Am. Vet. Med. Ass. 227, 775-777.
McClure, S.R., White, G.W., Sifferman, R.L., Bernard, W., Doucet, M.Y., Vrins, A., Holste, J.E., Fleishman, C., Alva, R. and Cramer, L.G. (2005b)
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