IN-DEPTH: CONDITIONS AND MANAGEMENT OF THE PERIPARTUM MARE
pregnant mare.63 Similarly, fetal oxygenation must be maintained and maternal problems that affect uterine circulation may have significant det- rimental effects. Maternal endotoxemia and the production of pro-inflammatory mediators in mater- nal disease will clearly have the potential for a range of negative effects on the fetus. Finally, maternal drug therapies, which may be essential for treat- ment of maternal disease and even critical to the mare’s survival, may have unintended or unknown consequences on the fetus.64 Although some stud- ies have investigated the placental transfer of drugs, in general there is only sparse information on drug metabolism and safety in pregnant mares and the fetus is considered to be potentially at greater risk due to its limited ability to metabolize and eliminate the majority of drugs and compounds it may be exposed to. Monitoring such mares to determine fetal health status is essential.
16. Conclusions
Recognizing a potentially compromised pregnancy can be difficult. Maternal and/or fetal conditions that threaten pregnancy can occur with few signs, thus limiting the ability of a veterinarian to manage the condition appropriately. However, some conditions are more predictable and adopting a policy of mid-to-late pregnancy surveillance to de- tect the subtle signs of disease can be rewarding.
Acknowledgments
Declaration of Ethics The Author has adhered to the Principles of Veter- inary Medical Ethics of the AVMA.
Conflict of Interest The Author has no conflicts of interest.
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