joints (23.6 4.2 ng/mL) at parturition. Neither mares nor foals presented clinical signs of doxycy- cline toxicity (e.g., diarrhea and jaundice). This is the first study to demonstrate that doxycycline crosses the equine placenta. While additional lon- gitudinal studies assessing potential side effects of doxycycline on foals born from treated mares are needed, doxycycline may be a useful drug to treat various infections in pregnant mares.
Acknowledgments
Declaration of Ethics The Authors have adhered to the Principles of Veter- inary Medical Ethics of the AVMA.
Conflict of Interest The Authors have no conflicts of interest.
Funding Sources
This study was funded by the Department of Veteri- nary Clinical Medicine, University of Illinois–Urbana- Champaign. Doxycycline was kindly provided by the Rood and Riddle Veterinary Pharmacy. CNPq id ac- knowledged for a master science scholarship CNPq funded to F.T.D.R.D.
Footnote a
Doxycycline, Rood and Riddle Pharmacy, Lexington KY 40511.
