EQUINE VETERINARY EDUCATION / AE / OCTOBER 2014


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Fig 5: Post mortem: cut surface (white arrow) of the enlarged, haemorrhagic, necrotic, haemangiosarcoma-invaded multilobular right deep inguinal lymph node.


Fig 7: Post mortem: craniocaudal (left) and lateromedial (right) radiographs of the disembodied right femur, with lateral and cranial to the left respectively, showing the moderate osteopaenia (white arrow) and comminuted fracture (arrowhead).


200 µm


Fig 8: Intramuscular focal haemangiosarcoma showing vascular channel formation (white arrows), robust extravascular connective tissue (black arrow) and occasional fibrin (arrowhead).


Fig 6: Post mortem: right hindlimb suspended fromthe hoof showing the massive lateral haematoma (white arrow) between muscle bellies of the biceps femoris muscle (arrowheads).


haemorrhage and necrosis with more peripheral tumour presence and compression of remaining lymphoid tissue to below the capsule. Factor VIII-related antigen IMH staining showed the better differentiated intramuscular tumours forming vascular channels to have strong endothelial cell cytoplasmic staining (Fig 9), whereas the solid tumours had scant staining. Although there was some loss of cellular detail


and IMH staining caused by the decalcification, there was evidence of haemangiosarcoma involving the periosteum in the region of the fracture (Fig 10), with occasional round, cell-dense tumour emboli within the marrow cavity. The bone shards at the fracture site were necrotic on histopathological examination. The tumour was interpreted as having arisen periosteally or intramuscularly with muscle and bone invasion, rather than from the bone marrow.


Diagnosis A post mortem diagnosis of disseminated haemangiosarcoma, affecting the right hindlimb musculature, epicardium, myocardium, pleura, peritoneum, deep inguinal lymph node, mesentery and leading to a pathological femur fracture was made.


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