LAMENESS: DIAGNOSTIC ANALGESIA, MEDICATIONS, AND PHYSIOLOGIC EFFECTS 3. Results
No adverse treatment effects were observed. When comparing MSC versus placebo-injected OA joints, there were significant improvements in range of mo- tion and effusion in the week after injection, higher
glycosaminoglycan (GAG) content of opposing third- carpal bone cartilage, significantly improved gene expression of cartilage matrix metalloproteinase-13 and synovial membrane IL-1, and reduced synovial fibrosis.
