IN-DEPTH: GERIATRIC MEDICINE/METABOLICS
pars intermedia dysfunction in aged horses. Equine Vet J 2013;45(1):74–79.
2. Treiber KH, Kronfeld DS, Hess TM, et al. Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies. JAmVet Med Assoc 2006;228:1538–1545.
3. Carter RA, Treiber KH, Geor RJ, et al. Prediction of incip- ient pasture-associated laminitis from hyperinsulinaemia, hyperleptinaemia and generalised and localised obesity in a cohort of ponies. Equine Vet J 2009;41:171–178.
4. Asplin KE, Sillence MN, Pollitt CC, et al. Induction of lami- nitis by prolonged hyperinsulinaemia in clinically normal ponies. Vet J 2007;174:530–535.
5. de Laat MA, McGowan CM, Sillence MN, et al. Equine laminitis: induced by 48 h hyperinsulinaemia in Standard- bred horses. Equine Vet J 2010;42:129–135.
6. Frank N, Andrews FM, Sommardahl CS, et al. Evaluation of the combined dexamethasone suppression/thyrotropin- releasing hormone stimulation test for detection of pars in- termedia pituitary adenomas in horses. J Vet Intern Med 2006;20:987–993.
7. Innera M, Petersen AD, Desjardins DR, et al. Comparison of hair follicle histology between horses with pituitary pars intermedia dysfunction and excessive hair growth and nor- mal aged horses. Vet Dermatol 2013;24:212–247.
8. Perkins GA, Lamb S, Erb HN, et al. Plasma adrenocortico- tropin (ACTH) concentrations and clinical response in horses treated for equine Cushing’s disease with cyproheptadine or pergolide. Equine Vet J 2002;34:679–685.
9. Frank N, Elliott SB, Chameroy KA, et al. Association of season and pasture grazing with blood hormone and metab- olite concentrations in horses with presumed pituitary pars intermedia dysfunction. J Vet Intern Med 2010;24:1167– 1175.
10. Place NJ, McGowan CM, Lamb SV, et al. Seasonal varia- tion in serum concentrations of selected metabolic hormones in horses. J Vet Intern Med 2010;24:650–654.
11. Beech J, Boston R, Lindborg S, et al. Adrenocorticotropin concentration following administration of thyrotropin-releas- ing hormone in healthy horses and those with pituitary pars intermedia dysfunction and pituitary gland hyperplasia. J Am Vet Med Assoc 2007;231:417–426.
12. Beech J, Garcia M. Hormonal response to thyrotropin-re- leasing hormone in healthy horses and in horses with pitu- itary adenoma. Am J Vet Res 1985;46:1941–1943.
13. Frank N, Geor RJ, Bailey SR, et al. Equine metabolic syn- drome. J Vet Intern Med 2010;24:467–475.
14. Durham AE, Hughes KJ, Cottle HJ, et al. Type 2 diabetes mellitus with pancreatic beta cell dysfunction in 3 horses confirmed with minimal model analysis. Equine Vet J 2009; 41:924–929.
15. Schuver A, Frank N, Chameroy K, et al. Use of an oral sugar test to assess insulin sensitivity in healthy and insulin- resistant horses. J Vet Intern Med 2010;24:780 [abstract].
16. McCue M, Schutlz NE, Martinson K, et al. Characterization of the equine metabolic syndrome phenotype, part I: biochem-
istry, morphometrics and breed comparisons. Proceedings of the American Veterinary Internal Medicine Forum, New Orleans, LA: 2012.
17. Wooldridge AA, Edwards HG, Plaisance EP, et al. Evalua- tion of high-molecular weight adiponectin in horses. Am J Vet Res 2012;73:1230–1240.
18. Suagee JK, Corl BA, Crisman MV, et al. Relationships be- tween body condition score and plasma inflammatory cyto- kines, insulin, and lipids in a mixed population of light-breed horses. J Vet Intern Med 2013;27(1):157–163.
19. Nielsen BD, Vick MM, Dennis PM. A potential link between insulin resistance and iron overload disorder in browsing rhinoceroses investigated through the use of an equine model. J Zoo Wildl Med 2012;43:S61–65.
20. Donaldson MT, LaMonte BH, Morresey P, et al. Treatment with pergolide or cyproheptadine of pituitary pars intermedia dysfunction (equine Cushing’s disease). J Vet Intern Med 2002;16:742–746.
21. Vick MM, Adams AA, Murphy BA, et al. Relationships among inflammatory cytokines, obesity, and insulin sensitiv- ity in the horse. J Anim Sci 2007;85:1144–1155.
22. Thatcher CD, Pleasant RS, Geor RJ, et al. Prevalence of overconditioning in mature horses in Southwest Virginia dur- ing the summer. J Vet Intern Med 2012;26:1413–1418.
23. Argo CM, Curtis GC, Grove-White D, et al. Weight loss resistance: a further consideration for the nutritional man- agement of obese equidae. Vet J 2012;194:179–188.
24. Frank N, Buchanan BR, Elliott SB. Effects of long-term oral administration of levothyroxine sodium on serum thyroid hormone concentrations, clinicopathologic variables, and echocardiographic measurements in healthy adult horses. Am J Vet Res 2008;69:68–75.
25. Frank N, Elliott SB, Boston RC. Effects of long-term oral administration of levothyroxine sodium on glucose dynamics in healthy adult horses. Am J Vet Res 2008;69:76–81.
26. Sommardahl CS, Frank N, Elliott SB, et al. Effects of oral administration of levothyroxine sodium on serum concentra- tions of thyroid gland hormones and responses to injections of thyrotropin-releasing hormone in healthy adult mares. Am J Vet Res 2005;66:1025–1031.
27. Toth F, Frank N, Geor RJ, et al. Effects of pretreatment with dexamethasone or levothyroxine sodium on endotoxin- induced alterations in glucose and insulin dynamics in horses. Am J Vet Res 2010;71:60–68.
28. Tinworth KD, Edwards S, Noble GK, et al. Pharmacokinet- ics of metformin after enteral administration in insulin- resistant ponies. Am J Vet Res 2010;71:1201–1206.
29. Durham AE, Rendle DI, Rutledge F, et al. The effects of metformin hydrochloride on intestinal glucose absorption and use of tests for hyperinsulinaemia. ACVIM Forum; New Orleans, Louisiana: 2012.
aKaro Light; ACH Food Companies, Inc, Cordova, TN 38016. bPrascend; Boehringer Ingelheim Vetmedica, Inc, St Joseph,
MO 64506.
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