IN-DEPTH INTERACTIVE: REPRODUCTIVE DISORDERS – PATHOLOGY TO TREATMENT Conflict of Interest
Portions of this material were generously supported through funding by the Grayson Jockey Club Re- search Foundation and the University of Florida Research Endowment (ceftiofur and firocoxib stud- ies for placentitis), Zoetis Animal Health (ceftiofur), Merial Animal Health (firocoxib) and Merck Animal Health (altrenogest).
References and Footnotes
1. Kotilainen T, Huhtinen M, Katila T. Sperm-induced leu- kocytosis in the equine uterus. Theriogenology 1994;41: 629–636.
2. Hughes JP, Loy RG. The relation of infection to infertility in the mare and stallion. Equine Vet J 1975;7:155–159.
3. Britton BA. Endometrial change in the annual reproduc- tive cycle of the mare. J Reprod Fertil Suppl 1982;32:175– 180.
4. LeBlanc MM, Neuwirth L, Asbury AC, et al. Scintigraphic measurement of uterine clearance in normal mares and mares with recurrent endometritis. Equine Vet J 1994;26: 109–113.
5. LeBlanc MM, Neuwirth L, Jones L, et al. Differences in uterine position of reproductively normal mares and those with delayed uterine clearance detected by scintigra- phy. Theriogenology 1998;50:49–54.
6. Neuwirth L, LeBlanc MM, Mauragis D, et al. Scintigraphic measurement of uterine clearance in mares. Vet Radiol Ultrasound 1995;36:64–68.
7. Causey RC, Ginn PS, Katz BP, et al. Mucus production by endometrium of reproductively healthy mares and mares with delayed uterine clearance. J Reprod Fertil Suppl 2000;56:333–339.
8. LeBlanc MM, Causey RC. Clinical and subclinical endome- tritis in the mare: both threats to fertility. Reprod Do- mest Anim 2009;44(suppl 3):10–22.
9. Clutterbuck AL, Woods EJ, Knottenbelt DC, et al. Biofilms and their relevance to veterinary medicine. Vet Microbiol 2007;125:390–390.
10. LeBlanc MM. How to perform and interpret findings from a low-volume uterine flush, in Proceedings. Am Assoc Equine Pract 2011;57:32–36.
11. Costerton JW, Lewandowski Z, Caldwell DE, et al. Micro- bial biofilms. Annu Rev Microbiol 1995;49:711–745.
12. Sutherland IW. The biofilm matrix - an immobilized but dynamic microbial environment. Trends Microbiol 2001;9: 222–227.
13. Ferris RA, Veir JK, Lappin MR, et al. Development and comparison of sampling techniques for a broad range, semi- quantitative polymerase chain reaction assay for detection of bacterial DNA in the equine uterus. J Equine Vet Sci 2014;34:687–693.
14. McKinnon AO, Squires EL, Harrison LA, et al. Ultrasono- graphic studies on the reproductive tract of mares after parturition: effect of involution and uterine fluid on preg- nancy rates in mares with normal and delayed first postpar- tum ovulatory cycles. J Am Vet Med Assoc 1988;192: 350–353.
15. Allen WE, Pycock JF. Cyclical accumulation of uterine fluid in mares with lowered resistance to endometritis. Vet Record 1988;122:489–490.
16. Pycock JF, Newcombe JR. The relationship between in- traluminal uterine fluid, endometritis, and pregnancy rate in the mare. Equine Pract 1996;18:19–22.
17. Riddle WT, LeBlanc MM, Stromberg AJ. Relationships be- tween uterine culture, cytology and pregnancy rates in a Thoroughbred practice. Theriogenology 2007;68:395–402.
18. Kozdrowski R, Sikora M, Buczkowska J, et al. Effects of cycle stage and sampling procedure on interpretation of endometrial cytology in mares. Anim Reprod Sci 2015;154: 56–62.
294 2015 Vol. 61 AAEP PROCEEDINGS
19. Ball BA, Shin SJ, Patten VH, et al. Use of a low-volume uterine flush for microbiologic and cytologic examination of the mare’s endometrium. Theriogenology 1988;29:1269– 1283.
20. LeBlanc MM, Magsig J, Stromberg AJ. Use of a low-vol- ume uterine flush for diagnosing endometritis in chronically infertile mares. Theriogenology 2007;68:403–412.
21. Vanderwall DK. How to process a dilute ejaculate of semen for cooled transported insemination, in
Proceedings.Am Assoc Equine Pract 2008;54:369–373.
22. Kenney RM. Prognostic value of endometrial biopsy of the mare. J Reprod Fertil Suppl 1975;23:347–348.
23. Esteller-Vico A, Liu IK, Couto S. Uterine vascular degen- eration is present throughout the uterine wall of multipa- rous mares. Colinearity between elastosis, endometrial grade, age and parity. Theriogenology 2012;78:1078–1084.
24. Esteller-Vico A, Liu IK, Brosnan RJ, et al. Uterine vascu- lar elastosis and its effect on uterine blood flow in cyclic mares. Anim Reprod Sci 2010;121:87–88.
25. Nielsen JM, Troedsson MH, Pedersen MR, et al. Diagnosis of endometritis in the mare based on bacteriological and cytological examinations of the endometrium: comparison of results obtained by swabs and biopsies. J Equine Vet Sci 2010;30:27–30.
26. Nielsen JM, Nielsen FH, Petersen MR. Diagnosis of equine endometritis—microbiology, cytology and histology of endo- metrial biopsies and the correlation to fertility. Pferdehei- lkunde 2012;28:8–13.
27. Nielsen JM. Endometritis in the mare: a diagnostic study comparing cultures from swab and biopsy. Theriog- enology 2005;64:510–518.
28. Arnold CE, Brinsko SP, Varner DD. Cervical wedge resec- tion for treatment of pyometra secondary to transluminal cervical adhesions in six mares. J Am Vet Med Assoc 2015; 246:1354–1357.
29. Card CE, Eaton SL. How to perform a hysteroscopically assisted endometrial biopsy and foreign body retrieval in mares, in Proceedings. Am Assoc Equine Pract 2010;56: 328–330.
30. LeBlanc MM, Neuwirth L, Mauragis D, et al. Oxytocin enhances clearance of radiocolloid from the uterine lumen of reproductively normal mares and mares susceptible to en- dometritis. Equine Vet Educ 1994;26:279–282.
31. Paccamonti DL, Pycock JF, Taverne MAM, et al. PGFM response to exogenous oxytocin and determination of the half-life of oxytocin in nonpregnant mares. Equine Vet J 1999;31:285–288.
32. Combs CB, LeBlanc MM, Neuwirth L, et al. Effects of prostaglandin F-2 alpha cloprostenol and fenprostalene on uterine clearance of radiocolloid in the mare. Theriogenol- ogy 1996;45:1449–1455.
33. Troedsson MHT, Ababneh MM, Ohlgren AF, et al. Effect of periovulatory prostaglandin F-2 alpha on pregnancy rates and luteal function in the mare. Theriogenology 2001;55: 1891–1899.
34. Nie GJ, Johnson KE, Wenzel JG, et al. Effect of adminis- tering oxytocin or cloprostenol in the periovulatory period on pregnancy outcome and luteal function in mares. Theriog- enology 2003;60:1111–1118.
35. Nie GJ, Johnson KE, Wenzel JG, et al. Luteal function in mares following administration of oxytocin, cloprostenol or saline on day 0, 1 or 2 post-ovulation. Theriogenology 2003; 60:1119–1125.
36. Brinsko SP, Varner DD, Blanchard TL. The effect of uter- ine lavage performed 4 hours post insemination on preg- nancy rate in mares. Theriogenology 1991;35:1111–1119.
37. Vanderwall DK, Woods GL. Effect on fertility of uterine lavage performed immediately prior to insemination in mares. J Am Vet Med Assoc 2003;222:1108–1110.
38. Brinsko SP, Varner DD, Blanchard TL, et al. The effect of postbreeding uterine lavage on pregnancy rate in mares. Theriogenology 1990;33:465–475.
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