CUTTING EDGE, NEW TOPICS, AND PRACTICAL INFORMATION IN THERIOGENOLOGY
and control stimulation. Total sperm count, motility, and testicular volume were reduced in acyline-treated stallions (P0.05). Testicular volume and most sem- inal parameters returned to normal values within 72 days after treatment discontinuation. Sperm output was normal by 7 months after the end of the experiment.
4. Discussion
Acyline reversibly suppressed the stallion HPG axis, and peripheral testosterone concentrations were re- duced to gelding levels. These findings warrant the investigation of acyline in equine arteritis virus (EAV) carrier stallions as a possible means of eliminating the androgen-dependent carrier state of EAV.
Acknowledgments
This study was funded by Albert Clay, Shapiro and Koller endowments from the Gluck Center, Univer-
sity of Kentucky. The paper (abstract) was reviewed by the principal investigators responsible for the research directed endowments.
Declaration of Ethics
The Authors declare that they have adhered to the Principles of Veterinary Medical Ethics of the AVMA.
Conflict of Interest The Authors declare no conflicts of interest.
Note
There are no FDA-approved veterinary acyline products avail- able so a compounded product was used.
