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THERIOGENOLOGY AND LAMENESS 5. Wingen F, Schma ¨hl D. Pharmacokinetics of the osteotro-


phic diphosphonate 3-amino-1-hydroxypropane-1,1- diphosphonic acid in mammals. Arzneim-Forsch/Drug Res 1987;37:1037–1042.


6. Rogers MJ, Crockett JC, Coxon FP, et al. Biochemical and molecular mechanisms of action of bisphosphonates. Bone 2011;49:34–41.


7. Zhang Q, Badell IR, Schwarz EM, et al. Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2. Ar- thritis Rheum 2005;52:2708–2718.


8. Sutherland KA, Rogers HL, Tosh D, et al. RANKL increases the level of Mxl-1 in osteoclasts and reduces bisphosphonate- induced osteoclast apoptosis in vitro. Arthritis Res Ther 2009;11:R58.


9. Sahni M, Guenther HL, Fleisch H, et al. Bisphosphonates act on rat bone resorption through the mediation of osteo- blasts. J Clin Invest 1993;91:2004–2011.


10. Nishikawa M, Akatsu T, Katayama Y, et al. Bisphospho- nates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures. Bone 1996;18:9–14.


11. Vitte ´ C, Fleisch H, Guenther HL. Bisphosphonates induce


osteoblasts to secrete an inhibitor of osteoclast-mediated re- sorption. Endocrinology 1996;137:2324–2333.


12. Bellido T, Plotkin LI. Novel actions of bisphosphonates in bone: preservation of osteoblast and osteocyte viabil- ity. Bone 2011;49:50–55.


13. Plotkin LI. Apoptotic osteocytes and the control of targeted bone resorption. Curr Osteoporos Rep 2014;12:121–126.


14. Bonjour JP, Ammann P, Barbier A, et al. Tiludronate: bone pharmacology and safety. Bone 1995;17:473S–477S.


15. Varela A, Lepage OM, Doucet M, et al. Tiludronate chez le cheval: Tolerance et effets a court terme sur le metabolism osseux. Ann Med Vet 2002;146:123–130.


16. Delguste C, Amory H, Guyonnet J, et al. Comparative phar- macokinetics of two intravenous administration regimens of tiludronate in healthy adult horses and effects on the bone resorption marker CTX-1. J Vet Pharmacol Ther 2008;31: 108–116.


17. Lee SH, Chang SS, Lee M, et al. Risk of osteonecrosis in patients taking bisphosphonates for prevention of osteoporo- sis: A systematic review and meta-analysis. Osteoporos Int 2014;25:1131–1139.


18. Liu J, Zhang HX, Lu XX, et al. Bisphosphonates and risk of subtrochanteric, femoral shaft, and atypical femur fracture: Sensitivity and trim and fill studies. Genet Test Mol Bio- markers 2014;18:117–122.


19. Saita Y, Ishijima M, Kaneko K. Atypical femoral fractures and bisphosphonate use: Current evidence and clinical im- plications. Ther Adv Chronic Dis 2015;6:185–193.


20. FDA Freedom of Information Summary Tildren. 2014;NADA 141–420. Accessed from: http://www.fda.gov/downloads/ AnimalVeterinary/Products/ApprovedAnimalDrugProducts/ FOIADrugSummaries/UCM408781.pdf.


21. FDA Freedom of Information Summary Osphos. 2014;NADA 141–427. Accessed from: http://www.fda.gov/downloads/ AnimalVeterinary/Products/ApprovedAnimalDrugProducts/ FOIADrugSummaries/UCM406997.pdf.


22. Denoix JM, Thibaud D, Riccio B. Tiludronate as a new thera- peutic agent in the treatment of navicular disease: A double- blind placebo-controlled clinical trial. Equine Vet J 2003;35: 407–413.


23. Whitfield CT, Schoonover MJ, Holbrook TC, et al. Quanti- tative assessment of two methods of tiludronate administra- tion for the treatment of lameness caused by navicular syndrome in horses. Am J Vet Res 2016;77:167–173.


24. Duesterdieck-Zellmer KF, Driscoll N, Ott J. Concentration- dependent effects of tiludronate on equine articular cartilage explants incubated with and without interleukin-1. Am J Vet Res 2012;73:1530–1539.


25. Duesterdieck-Zellmer KF, Moneta L, Ott JF, et al. Effects of low and high dose intraarticular tiludronate on synovial fluid and clinical variables in healthy horses—A preliminary in- vestigation. Peer J 2014;2:e534.


26. Hunter BG, Duesterdieck-Zellmer KF, Larson MK. Tiludro- nate concentrations and cytologic findings in synovial fluid after intravenous regional limb perfusion with tiludronate in horses. Peer J 2015;3:e889.


27. Castan ˜eda S, Roman-Blas JA, Largo R, et al. Subchondral


bone as a key target for osteoarthritis treatment. Biochem Pharmacol 2012;83:315–323.


28. Burr DB, Gallant MA. Bone remodelling in osteoarthritis. Nat Rev Rheumatol 2012;8:665–673.


29. Bellido M, Lugo L, Roman-Blas JA, et al. Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis. Ar- thritis Res Ther 2010;12:R152.


30. Coudry V, Thibaud D, Riccio B, et al. Efficacy of tiludronate in the treatment of horses with signs of pain associated with osteoarthritic lesions of the thoracolumbar vertebral column. Am J Vet Res 2007;68(3):329–337.


31. Gough MR, Thibaud D, Smith RK. Tiludronate infusion in the treatment of bone spavin: A double blind placebo- controlled trial. Equine Vet J 2010;42:381–387.


32. Delguste C, Armory H, Doucet M, et al. Pharmacological effects of tiludronate in horses after long-term immobiliza- tion. Bone 2007;41:414–421.


33. Kates SL, Ackert-Bicknell CL. How do bisphosphonates af- fect fracture healing? Injury 2016;47(S1):S65–S68.


34. Xue D, Li F, Chen G, et al. Do bisphosphonates affect bone healing? A meta-analysis of randomized controlled trials. J Orthop Surg Res 2014;9:45.


35. Li YT, Cai HF, Zhang ZL. Timing of the initiation of bis- phosphonates after surgery for fracture healing: A system- atic review and meta-analysis of randomized controlled trials. Osteoporos Int 2015;26:431–441.


36. Savaridas T, Wallace RJ, Salter DM, et al. Do bisphospho- nates inhibit direct fracture healing? A laboratory investi- gation using an animal model. Joint J 2013;95-B:1263– 1268.


37. Carpenter RS. How to treat dorsal metacarpal disease with regional tiludronate and extracorporeal shock wave therapies in Thoroughbred race horses, in Proceedings. Am Assoc Equine Pract 58:546–549, 2012.


38. Wilkinson JM, Little DG. Bisphosphonates in orthopedic applications. Bone 2011;49:95–102.


39. Baroncelli GI, Bertelloni S. The use of bisphosphonates in pediatrics. Horm Res Paediatr 2014;82:290–302.


40. Land C, Rauch F, Glorieux FH. Cyclical intravenous pamidronate treatment affects metaphyseal modeling in growing patients with osteogenesis imperfect. J Bone Min Res 2006;21:374–379.


41. Green SB, Pappas AL. Effects of maternal bisphosphonate use on fetal and neonatal outcomes. Am J Health Syst Pharm 2014;71:2029–2036.


42. Smith EJ, Little DG, Briody JN, et al. Transient distur- bance in physeal morphology is associated with long-term effects of nitrogen-containing bisphosphonates in growing rabbits. J Bone Min Res 2005;20:1731–1541.


43. Thibaud D, Guyonnet J, Toutain PL. Pharmacological ap- proaches of dose determination with tiludronate for use in the horse. J Vet Pharmacol Ther 26(Suppl 1):200–201, 2003 (Abstract).


aTildren, Ceva Animal Health LLC, Lenexa, KS 66215. bOsphos, Dechra Veterinary Products, Overland Park, KS


66211. c


VersaTron, PulseVet, Alpharetta, GA 30009.


378 2016  Vol. 62  AAEP PROCEEDINGS


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