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MANAGEMENT OF HYPERINSULINAEMIA


Cree- Green , M. , Bergman , B.C. , Cengiz , E. , Fox , L.A. , Hannon , T.S. , Miller , K. et al. ( 2019 ) Metformin improves peripheral insulin sensitivity in youth with type 1 diabetes . Journal of Clinical Endocrinology and Metabolism , 104 , 3265 – 3278 .


de Laat , M. , McGowan , C. , Sillence , M. & Pollitt , C.C. ( 2010 ) Equine laminitis:


induced by 48 h hyperinsulinaemia in Standardbred


horses: equine laminitis: induced by 48 h hyperinsulinaemia . Equine Veterinary Journal , 42 , 129 – 135 .


de Laat , M.A. , Hampson , B.A. , Sillence , M.N. & Pollitt , C.C. ( 2016 ) Sustained, low- intensity exercise achieved by a dynamic feeding system decreases body fat in ponies . Journal of Veterinary Internal Medicine , 30 , 1732 – 1738 .


de Laat , M.A. , McGree , J.M. & Sillence , M.N. ( 2016 ) Equine hyperinsulin- emia: investigation of the enteroinsular axis during insulin dysregu- lation . American Journal of Physiology. Endocrinology and Metabolism , 310 , E61 – E72 .


de Laat , M.A. & Sillence , M.N. ( 2017 ) The repeatability of an oral glucose test in ponies . Equine Veterinary Journal , 49 , 238 – 243 .


de Laat , M.A. & Sillence , M.N. ( 2020 ) A review of recent developments in the pharmacological prevention and treatment of endocrinopathic laminitis . Animal Production Science , 60 , 2111 .


de Laat , M.A. , Warnken , T. , Delarocque , J. , Reiche , D.B. , Grob , A.J. , Feige , K. et al. ( 2022 ) Carbohydrate pellets to assess insulin dysregulation in horses . Journal of Veterinary Internal Medicine , 37 , 302 – 314 .


Delarocque , J. , Feige , K. , Carslake , H.B. , Durham , A.E. , Fey , K. & Warnken , T. ( 2023 ) Development of a web app to convert blood insulin con- centrations among various immunoassays used in horses . Animals | An Open Access Journal from MDPI , 13 , 2704 .


Donnan , J.R. , Grandy , C.A. , Chibrikov , E. , Marra , C.A. , Aubrey- Bassler , K. , Johnston , K. et al. ( 2019 ) Comparative safety of the sodium glucose co- transporter 2 (SGLT2) inhibitors: a systematic review and meta- analysis . British Medical Journal Open , 9 , e022577 .


Dosi , M.C.M. , Kirton , R. , Hallsworth , S. , Keen , J.A. & Morgan , R.A. ( 2020 ) Inducing weight loss in native ponies: is straw a viable alternative to hay? Veterinary Record , 187 , e60 .


Dugdale , A.H.A. , Curtis , G.C. , Cripps , P. , Harris , P.A. & Argo , C.M.G. ( 2010 ) Effect of dietary restriction on body condition, composition and welfare of overweight and obese pony mares . Equine Veterinary Journal , 42 , 600 – 610 .


Durham , A. , Rendle , D. & Newton , J. ( 2008 ) The effect of metformin on measurements of insulin sensitivity and β cell response in 18 horses and ponies with insulin resistance . Equine Veterinary Journal , 40 , 493 – 500 .


Durham , A.E. ( 2016 ) Endocrine disease in aged horses . Veterinary Clinics of North America: Equine Practice , 32 , 301 – 315 .


Durham , A.E. ( 2017 ) Therapeutics for equine endocrine disorders . Veterinary Clinics of North America: Equine Practice , 33 , 127 – 139 .


Durham , A.E. , Frank , N. , McGowan , C.M. , Menzies- Gow , N.J. , Roelfsema , E. , Vervuert , I. et al. ( 2019 ) ECEIM consensus statement on equine metabolic syndrome . Journal of Veterinary Internal Medicine , 33 , 335 – 349 .


Durham , A.E. , Hughes , K.J. , Cottle , H.J. , Rendle , D.I. & Boston , R.C. ( 2009 ) Type 2 diabetes mellitus with pancreatic β cell dysfunction in 3 horses confirmed with minimal model analysis . Equine Veterinary Journal , 41 , 924 – 929 .


Durham , A.E. , McGowan , C.M. , Fey , K. , Tamzali , Y. & van der Kolk , J.H. ( 2014 ) Pituitary pars intermedia dysfunction: diagnosis and treat- ment: diagnosis and treatment of PPID . Equine Veterinary Education , 26 , 216 – 223 .


EEG . ( 2022 ) Equine Endocrinology Group: Recommendations for the Diagnosis and Management of Equine Metabolic Syndrome (EMS) . https:// sites. tufts. edu/ equin eendo group/ . Accessed 2 January 2023


Figueiredo , I.R. , Rose , S.C.P. , Freire , N.B. , Patrocínio , M.S. , Pierdoná , N. & Bittencourt , R.J. ( 2018 ) Use of sodium- glucose cotransporter- 2 inhibitors and urinary tract infections in type 2 diabetes patients:


| 333


a systematic review . Revista Da Associacao Medica Brasileira , 65 , 246 – 252 .


Firshman , A.M. & Valberg , S.J. ( 2007 ) Factors affecting clinical assess- ment of insulin sensitivity in horses . Equine Veterinary Journal , 39 , 567 – 575 .


Frank , N. ( 2018 ) Safety and efficacy of Canagliflozin and octreotide for managing insulin dysregulation in horses . Journal of Veterinary Internal Medicine , 32 , 2123 – 2143 .


Frank , N. , Buchanan , B. & Elliott , S. ( 2008 ) Effects of long- term oral administration of levothyroxine sodium on serum thyroid hor- mone concentrations, clinicopathologic variables, and echocardio- graphic measurements in healthy adult horses . American Journal of Veterinary Research , 69 , 68 – 75 .


Frank , N. , Elliott , S.B. & Boston , R.C. ( 2008 ) Effects of long- term oral administration of levothyroxine sodium on glucose dynamics in healthy adult horses . American Journal of Veterinary Research , 69 , 76 – 81 .


Frank , N. & Tadros , E.M. ( 2014 ) Insulin dysregulation . Equine Veterinary Journal , 46 , 103 – 112 .


Frank , N. , Thane , K. , Voth , R. , Klee , R. & Warnken , T. ( 2023 ) The sodium- glucose cotransporter- 2 inhibitor velagliflozin decreases basal plasma insulin concentrations in horses with moderate- severe in- sulin dysregulation . In: ACVIM 2023, Philadelphia, USA.


Frias , J.P. ( 2019 ) Fixed- dose combination of ertugliflozin and metformin hydrochloride for the treatment of type 2 diabetes . Expert Review of Endocrinology and Metabolism , 14 , 75 – 83 .


Furtado , T. ( 2023 ) Motivating owners to change their behaviour to tackle obesity in their pets . Veterinary Record , 192 , 1 – 2 .


Furtado , T. , King , M. , Perkins , E. , McGowan , C. , Chubbock , S. , Hannelly , E. et al. ( 2022 ) An exploration of environmentally sustainable prac- tices associated with alternative grazing management system use for horses, ponies, donkeys and mules in the UK . Animals | An Open Access Journal from MDPI , 12 , 151 .


Furtado , T. , Perkins , E. , Pinchbeck , G. , McGowan , C. , Watkins , F. & Christley , R. ( 2021 ) Exploring horse owners ' understanding of obese body condition and weight management in UK leisure horses . Equine Veterinary Journal , 53 , 752 – 762 .


Geor , R.J. ( 2009 ) Pasture- associated laminitis . Veterinary Clinics of North America: Equine Practice , 25 , 39 – 50 . v–vi.


Gerich , J.E. ( 2010 ) Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implica- tions . Diabetic Medicine , 27 , 136 – 142 .


Glunk , E.C. , Sheaffer , C.C. , Hathaway , M.R. & Martinson , K.L. ( 2014 ) Interaction of grazing muzzle use and grass species on forage intake of horses . Journal of Equine Veterinary Science , 34 , 930 – 933 .


Goldenberg , R.M. , Berard , L.D. , Cheng , A.Y.Y. , Gilbert , J.D. , Verma , S. , Woo , V.C. et al. ( 2016 ) SGLT2 inhibitor–associated diabetic keto- acidosis: clinical review and recommendations for prevention and diagnosis . Clinical Therapeutics , 38 , 2654 – 2664.e1 .


Harris , P. ( 2023 ) Dietary Management of Laminitic Animals . In: ACVIM 2023, Philadelphia, USA.


Harris , P.A. , Ellis , A.D. , Fradinho , M.J. , Jansson , A. , Julliand , V. , Luthersson , N. et al. ( 2017 ) Review: feeding conserved forage to horses: recent advances and recommendations . Animal , 11 , 958 – 967 .


Henneke , D.R. , Potter , G.D. , Kreider , J.L. & Yeates , B.F. ( 1983 ) Relationship between condition score, physical measurements and body fat per- centage in mares . Equine Veterinary Journal , 15 , 371 – 372 .


Herman , R. , Kravos , N.A. , Jensterle , M. , Janež , A. & Dolžan , V. ( 2022 ) Metformin and insulin resistance: A review of the underlying mech- anisms behind changes in GLUT4- mediated glucose transport . International Journal of Molecular Sciences , 23 , 1264 .


Hodge , E. , Kowalski , A. , Torcivia , C. , Lindborg , S. , Stefanovski , D. , Hart , K. et al. ( 2019 ) Effect of thyrotropin- releasing hormone stimula- tion testing on the oral sugar test in horses when performed as a combined protocol . Journal of Veterinary Internal Medicine , 33 , 2272 – 2279 .


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