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Horn , R. , Bamford , N.J. , Afonso , T. , Sutherland , M. , Buckerfield , J. , Tan , R.H.H. et al. ( 2019 ) Factors associated with survival, lami- nitis and insulin dysregulation in horses diagnosed with equine pituitary pars intermedia dysfunction . Equine Veterinary Journal , 51 , 440 – 445 .


Hu , J. , Zou , P. , Zhang , S. , Zhou , M. & Tan , X. ( 2016 ) Empagliflozin/met- formin fixed- dose combination: a review in patients with type 2 di- abetes . Expert Opinion on Pharmacotherapy , 17 , 2471 – 2477 .


Hughes , K. , Hodgson , D. & Dart , A. ( 2004 ) Equine hyperlipaemia: a re- view . Australian Veterinary Journal , 82 , 136 – 142 .


Hustace , J.L. , Firshman , A.M. & Mata , J.E. ( 2009 ) Pharmacokinetics and bioavailability of metformin in horses . American Journal of Veterinary Research , 70 , 665 – 668 .


Husted , L. , Sanchez , L.C. , Baptiste , K.E. & Olsen , S.N. ( 2009 ) Effect of a feed/fast protocol on pH in the proximal equine stomach . Equine Veterinary Journal , 41 , 658 – 662 .


Ince , J. , Longland , A.C. , Newbold , J.C. & Harris , P.A. ( 2011 ) Changes in proportions of dry matter intakes by ponies with access to pasture and haylage for 3 and 20 hours per day respectively, for six weeks . Journal of Equine Veterinary Science , 31 , 283 .


Ireland , J.L. , Clegg , P.D. , McGowan , C.M. , Platt , L. & Pinchbeck , G.L. ( 2011 ) Factors associated with mortality of geriatric horses in the United Kingdom . Preventive Veterinary Medicine , 101 , 204 – 218 .


Jocelyn , N.A. , Harris , P.A. & Menzies- Gow , N.J. ( 2018 ) Effect of varying the dose of corn syrup on the insulin and glucose response to the oral sugar test . Equine Veterinary Journal , 50 , 836 – 841 .


Johnson , P.J. ( 2016 ) Endocrine and metabolic dysregulation in laminitis: Role of pituitary dysfunction . In: Belknap , J.K. & Geor , R.J. (Eds.) Equine Laminitis . New Jersey : Wiley , pp. 134 – 140 .


Johnson , P.J. , Wiedmeyer , C.E. , Messer , N.T. & Ganjam , V.K. ( 2009 ) Medical implications of obesity in horses—lessons for human obe- sity . Journal of Diabetes Science and Technology , 3 , 163 – 174 .


Karikoski , N.P. , Box , J.R. , Mykkänen , A.K. , Kotiranta , V.V. & Raekallio , M.R. ( 2022 ) Variation in insulin response to oral sugar test in a cohort of horses throughout the year and evaluation of risk factors for insulin dysregulation . Equine Veterinary Journal , 54 , 905 – 913 .


Karikoski , N.P. , Horn , I. , McGowan , T.W. & McGowan , C.M. ( 2011 ) The prevalence of endocrinopathic laminitis among horses presented for laminitis at a first- opinion/referral equine hospital . Domestic Animal Endocrinology , 41 , 111 – 117 .


Karikoski , N.P. , McGowan , C.M. , Singer , E.R. , Asplin , K.E. , Tulamo , R.- M. & Patterson- Kane , J.C. ( 2015 ) Pathology of natural cases of equine Endocrinopathic laminitis associated with hyperinsulinemia . Veterinary Pathology , 52 , 945 – 956 .


Karikoski , N.P. , Patterson- Kane , J.C. , Singer , E.R. , McFarlane , D. & McGowan , C.M. ( 2016 ) Lamellar pathology in horses with pitu- itary pars intermedia dysfunction . Equine Veterinary Journal , 48 , 472 – 478 .


Katz , L.M. & Bailey , S.R. ( 2012 ) A review of recent advances and cur- rent hypotheses on the pathogenesis of acute laminitis . Equine Veterinary Journal , 44 , 752 – 761 .


Kellon , E.M. & Gustafson , K.M. ( 2022 ) Use of the SGLT2 inhibitor cana- gliflozin for control of refractory equine hyperinsulinemia and lam- initis . Open Veterinary Journal , 12 , 511 – 518 .


Kellon , E.M. & Gustafson , K.M. ( 2023 ) Hypertriglyceridemia in equines with refractory hyperinsulinemia treated with SGLT2 inhibitors . Open Veterinary Journal , 13 , 365 – 375 .


Knowles , E. ( 2018 ) Glucocorticoids and laminitis: a real risk? UK- Vet Equine , 2 , 140 – 144 .


Knowles , E.J. , Elliott , J. , Harris , P.A. , Chang , Y. & Menzies- Gow , N.J. ( 2023 ) Predictors of laminitis development in a cohort of nonlami- nitic ponies . Equine Veterinary Journal , 55 , 12 – 23 .


Knowles , E.J. & Grieve , L. ( 2020 ) Clinical insights: equine obesity . Equine Veterinary Journal , 52 , 635 – 638 .


SUNDRA ET AL.


Knowles , E.J. , Harris , P. , Elliott , J. , Chang , Y. & Menzies- Gow , N.J. ( 2024 ) Factors associated with insulin responses to oral sugars in a mixed- breed cohort of ponies . Equine Veterinary Journal , 56 , 253 – 263 . Available from: https:// doi. org/ 10. 1111/ evj. 13983


Knowles , E.J. , Harris , P.A. , Elliott , J. & Menzies- Gow , N.J. ( 2017 ) Use of the oral sugar test in ponies when performed with or without prior fasting . Equine Veterinary Journal , 49 , 519 – 524 .


Kumar , A.S. , Maiya , A.G. , Shastry , B.A. , Vaishali , K. , Ravishankar , N. , Hazari , A. et al. ( 2019 ) Exercise and insulin resistance in type 2 di- abetes mellitus: A systematic review and meta- analysis . Annals of Physical and Rehabilitation Medicine , 62 , 98 – 103 .


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Lindåse , S. , Nostell , K. , Hanche- Olsen , K. , Hellings , I. , Fintl , C. & Bröjer , J. ( 2023 ) Short- term effects of canagliflozin on postprandial glucose and insulin responses – preliminary results from an ongoing ran- domized, double- blind, placebo- controlled study . In: Global Equine Endocrine Symposium, Bern, Switzerland.


List , J. & Whaley , J. ( 2011 ) Glucose dynamics and mechanistic im- plications of SGLT2 inhibitors in animals and humans . Kidney International , 79 , 20 – 27 .


Longland , A.C. , Barfoot , C. & Harris , P.A. ( 2011 ) Effects of soaking on the water- soluble carbohydrate and crude protein content of hay . Veterinary Record , 168 , 618 .


Longland , A.C. , Barfoot , C. & Harris , P.A. ( 2014 ) Effect of period, water temperature and agitation on loss of water- soluble carbohydrates and protein from grass hay: implications for equine feeding man- agement . Veterinary Record , 174 , 68 .


Longland , A.C. , Barfoot , C. & Harris , P.A. ( 2016a ) Effects of grazing muzzles on intakes of dry matter and water- soluble carbohydrates by ponies grazing spring, summer, and autumn swards, as well as autumn swards of different heights . Journal of Equine Veterinary Science , 40 , 26 – 33 .


Longland , A.C. , Barfoot , C. & Harris , P.A. ( 2016b ) Efficacy of wearing grazing muzzles for 10 hours per day on controlling bodyweight in pastured ponies . Journal of Equine Veterinary Science , 45 , 22 – 27 .


Macon , E.L. , Harris , P. , Bailey , S. , Barker , V.D. & Adams , A. ( 2022 ) Postprandial insulin responses to various feedstuffs differ in insulin dysregulated horses compared with non- insulin dysregulated con- trols . Equine Veterinary Journal , 54 , 574 – 583 .


Macon , E.L. , Harris , P. , Barker , V. & Adams , A. ( 2022 ) Seasonal insulin responses to the Oral sugar test in healthy and insulin dysregulated horses . Journal of Equine Veterinary Science , 113 , 103945 .


Macon , E.L. , Harris , P. , Partridge , E. , Barker , V.D. & Adams , A. ( 2021 ) Effect of dose and fasting on Oral sugar test responses in insu- lin dysregulated horses . Journal of Equine Veterinary Science , 107 , 103770 .


Marshall , J.B. , Kapcala , L.P. , Manning , L.D. & McCullough , A.J. ( 1984 ) Effect of corticotropin- like intermediate lobe peptide on pancre- atic exocrine function in isolated rat pancreatic lobules . Journal of Clinical Investigation , 74 , 1886 – 1889 .


McFarlane , D. ( 2011 ) Equine pituitary pars intermedia dysfunction . Veterinary Clinics of North America: Equine Practice , 27 , 93 – 113 .


McFarlane , D. , Johnson , P.J. & Schott , H.C. ( 2016 ) Pituitary pars interme- dia dysfunction . In: Belknap , J.K. & Geor , R.J. (Eds.) Equine Laminitis . New Jersey : Wiley , pp. 334 – 340 .


Meier , A. , de Laat , M. , Reiche , D. , Fitzgerald , D. & Sillence , M. ( 2019 ) The efficacy and safety of velagliflozin over 16 weeks as a treat- ment for insulin dysregulation in ponies . BMC Veterinary Research , 15 , 65 .


Meier , A. , Reiche , D. , de Laat , M. , Pollitt , C. , Walsh , D. & Sillence , M. ( 2018 ) The sodium- glucose co- transporter 2 inhibitor velagli- flozin reduces hyperinsulinemia and prevents laminitis in insulin- dysregulated ponies . PLoS ONE , 13 , e0203655 .


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