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MANAGEMENT OF HYPERINSULINAEMIA


Meier , A.D. , de Laat , M.A. , Reiche , D. , Pollitt , C. , Walsh , D. , McGree , J. et al. ( 2018 ) The oral glucose test predicts laminitis risk in ponies fed a diet high in nonstructural carbohydrates . Domestic Animal Endocrinology , 63 , 1 – 9 .


Memon , R.A. , Akbariromani , H. , Vohra , R.R. , Kundi , H. , Saleem , R.F. , Ghaffari , M. et al. ( 2022 ) Comparison of cardiovascular outcomes between Dapagliflozin and Empagliflozin in patients with type 2 di- abetes: A meta- analysis . Cureus , 14 , e27277 .


Menzies- Gow , N.J. , Harris , P.A. & Elliott , J. ( 2017 ) Prospective cohort study evaluating risk factors for the development of pasture- associated laminitis Journal , 49 , 300 – 306 .


in the United Kingdom . Equine Veterinary


Moore- Colyer , M.J.S. , Lumbis , K. , Longland , A. & Harris , P. ( 2014 ) The effect of five different wetting treatments on the nutrient con- tent and microbial concentration in Hay for horses . PLoS ONE , 9 , e114079 .


Morgan , R. , McGowan , T. & McGowan , C. ( 2014 ) Prevalence and risk factors for hyperinsulinaemia in ponies in Queensland, Australia . Australian Veterinary Journal , 92 , 101 – 106 .


Morgan , R.A. , Keen , J.A. & McGowan , C.M. ( 2016 ) Treatment of equine metabolic syndrome: A clinical case series . Equine Veterinary Journal , 48 , 422 – 426 .


Müller , C.E. , Nostell , K. & Bröjer , J. ( 2016 ) Methods for reduction of water soluble carbohydrate content in grass forages for horses . Livestock Science , 186 , 46 – 52 .


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renal events in type 2 diabetes . New England Journal of Medicine , 377 , 644 – 657 .


Obici , S. , Feng , Z. , Tan , J. , Liu , L. , Karkanias , G. & Rossetti , L. ( 2001 ) Central melanocortin receptors regulate insulin action . Journal of Clinical Investigation , 108 , 1079 – 1085 .


Owers , R. & Chubbock , S. ( 2012 ) Fight the fat! Equine Veterinary Journal , 45 , 5 .


Pollack , R. & Cahn , A. ( 2022 ) SGLT2 inhibitors and safety in older pa- tients . Heart Failure Clinics , 18 , 635 – 643 .


Puckrin , R. , Saltiel , M.- P. , Reynier , P. , Azoulay , L. , Yu , O.H.Y. & Filion , K.B. ( 2018 ) SGLT- 2 inhibitors and the risk of infections: a system- atic review and meta- analysis of randomized controlled trials . Acta Diabetologica , 55 , 503 – 514 .


Rendle , D. , Argo , C. , Bowen , M. , Carslake , H. , German , A. , Harris , P. et al. ( 2018 ) Equine obesity: current perspectives roundtable . UK- Vet Equine , 2 , 1 – 19 .


Rendle , D.I. , Rutledge , F. , Hughes , K.J. , Heller , J. & Durham , A.E. ( 2013 ) Effects of metformin on blood insulin and glucose responses . Equine Veterinary Journal , 45 , 751 – 754 .


Rieg , T. , Masuda , T. , Gerasimova , M. , Mayoux , E. , Platt , K. , Powell , D.R. et al. ( 2014 ) Increase in SGLT1- mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition


in euglycemia . American Journal of Physiology. Renal Physiology , 306 , F188 – F193 .


Rush , B.R. , Worster , A.A. , Flaminio , M.J. , Matson , C.J. & Hakala , J.E. ( 1998 ) Alteration in adrenocortical function in horses with recur- rent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively . American Journal of Veterinary Research , 59 , 1044 – 1047 .


Schmengler , U. , Ungru , J. , Boston , R. , Coenen , M. & Vervuert , I. ( 2013 ) Effects of l- carnitine supplementation on body weight losses and metabolic profile in obese and insulin- resistant ponies during a 14- week body weight reduction programme . Livestock Science , 155 , 301 – 307 .


Schmidt , D.W. , Argyropoulos , C. & Singh , N. ( 2021 ) Are the protective effects of SGLT2 inhibitors a “class- effect” or are there differences between agents? Kidney360 , 2 , 881 – 885 .


( 2017 ) Canagliflozin and cardiovascular and


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Schuver , A. , Frank , N. , Chameroy , K.A. & Elliott , S.B. ( 2014 ) Assessment of insulin and glucose dynamics by using an Oral sugar test in horses . Journal of Equine Veterinary Science , 34 , 465 – 470 .


Shepherd , M. , Harris , P. & Martinson , K.L. ( 2021 ) Nutritional consider- ations when dealing with an obese adult equine . Veterinary Clinics of North America: Equine Practice , 37 , 111 – 137 .


Silva , S.R. , Payan- Carreira , R. , Quaresma , M. , Guedes , C.M. & Santos , A.S. ( 2016 ) Relationships between body condition score and ul- trasound skin- associated subcutaneous fat depth in equids . Acta Veterinaria Scandinavica , 58 , 62 .


Singh , M. & Kumar , A. ( 2018 ) Risks associated with SGLT2 inhibitors: an overview . Current Drug Safety , 13 , 84 – 91 .


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Stewart- Hunt , L. , Geor , R. & McCutcheon , L. ( 2006 ) Effects of short- term training on insulin sensitivity and skeletal muscle glucose metabo- lism in Standardbred horses . Equine Veterinary Journal , 38 , 226 – 232 .


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insulin- sensitive horses . Domestic Animal Endocrinology , 40 , 173 – 181 .


Sundra , T. , Kelty , E. & Rendle , D. ( 2023 ) Preliminary observations on the use of ertugliflozin in the management of hyperinsulinaemia and laminitis in 51 horses: A case series . Equine Veterinary Education , 35 , 311 – 320 .


Sundra , T. , Lester , G. , Rossi , G. & Rendle , D. ( 2023 ) Sodium–glucose cotransporter 2 inhibitors in horses—magic bullet or latest fad? Equine Veterinary Journal , 55 , 559 – 562 .


Swisa , A. , Glaser , B. & Dor , Y. ( 2017 ) Metabolic stress and compromised identity of pancreatic Beta cells . Frontiers in Genetics , 08 , 21 .


Timko , K.J. , Hostnik , L.D. , Watts , M.R. , Chen , C. , Bercz , A. , Toribio , R.E. et al. ( 2022 ) Diagnostic evaluation of insulin and glucose dynamics in light- breed horses receiving dexamethasone . Canadian Veterinary Journal , 63 , 617 – 626 .


Tinworth , K.D. , Boston , R.C. , Harris , P.A. , Sillence , M.N. , Raidal , S.L. & Noble , G.K. ( 2012 ) The effect of oral metformin on insulin sensitiv- ity in insulin- resistant ponies . Veterinary Journal , 191 , 79 – 84 .


Treiber , K.H. , Kronfeld , D.S. , Hess , T.M. , Byrd , B.M. , Splan , R.K. & Staniar , W.B. ( 2006 ) Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture- associated laminitis in po- nies . Journal of the American Veterinary Medical Association , 228 , 1538 – 1545 .


Walsh , D.M. , McGowan , C.M. , McGowan , T. , Lamb , S.V. , Schanbacher , B.J. & Place , N.J. ( 2009 ) Correlation of plasma insulin concentration with laminitis score in a field study of equine Cushing ' s disease and equine metabolic syndrome . Journal of Equine Veterinary Science , 29 , 87 – 94 .


Wanner , C. , Inzucchi , S.E. , Lachin , J.M. , Fitchett , D. , von Eynatten , M. , Mattheus , M. et al. ( 2016 ) Empagliflozin and progression of kidney disease in type 2 diabetes . New England Journal of Medicine , 375 , 323 – 334 .


Watts , K.A. ( 2004 ) Forage and pasture management for laminitic horses . Clinical Techniques in Equine Practice , 3 , 88 – 95 .


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