INFLAMMATION, INFECTION, OR BOTH? ROOT CAUSES OF ENDOMETRITIS
and plasma against methicillin-resistant Staphylococcus aureus. Arch med vet 2011;43:155–161.
21. Bielecki TM, Gazdzik TS, Arendt J, et al. Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances. J Bone Joint Surg Br 2007;89:417–420.
22. Segabinazzi LGTM, Canisso IF. How to prepare platelet- rich plasma for use in reproductive practices with mares. AAEP proceedings vol. 67, 2021, 253–260.
23. Segabinazzi LGTM, Podico G, Rosser MF, et al. Three man- ual noncommercial methods to prepare equine platelet-rich plasma. Animals 2021;11:1478.
24. Dawod A, Miro J, Elbaz HT, et al. Effect of intrauterine infusion of equine fresh platelets-rich plasma (PRP) or ly- ophilized PRP (L-GFequina) on ovarian activity and preg- nancy rate in repeat breeder purebred Arabian mares. Animals 2021;11:1123.
25. Soares CS, Babo PS, Reis RL, et al. Platelet-derived prod- ucts in veterinary medicine: A new trend or an effective therapy? Trends Biotechnol 2020;20:30206–30207.
26. Roffi A, Filardo G, Assirelli E, et al. Does platelet-rich plasma freeze-thawing influence growth factor release and their effects on chondrocytes and synoviocytes? Biomed Res Int 2014;2014:692913.
27. Doucet C, Ernou I, Zhang Y, et al. Platelet lysates promote mesenchymal stem cell expansion: A safety substitute for animal serum in cell-based therapy applications. J Cell Physiol 2005;205:228–236.
28. Perrone G, et al. Treatment with platelet lysate inhibits pro- teases of synovial fluid in equines with osteoarthritis. J. Equine Vet. Sci 2020;88.
29. Tyrnenopoulou P, Diakakis N, Karayannopoulou M, et al. Evaluation of intra-articular injection of autologous platelet lysate (PL) in horses with osteoarthritis of the distal inter- phalangeal joint. Vet. Q 2016;36:56–62.
30. Colombo I, Mislei B, Mari G, et al. Effect of platelet lysate on uterine response of mares susceptible to persistent mat- ing-induced endometritis. Theriogenology 2022;179:204– 210.
31. Hraha TH, Doremus KM, Mcilwraith CW, et al. Autologous conditioned serum: The comparative cytokine profiles of two commercial methods (IRAP and IRAP II) using equine blood. Equine Vet J 2011;43:516–521.
32. Frisbie DD, Kawcak CE, Werpy NM, et al. Clinical, bio- chemical, and histologic effects of intra-articular adminis- tration of autologous conditioned serum in horses with experimentally induced osteoarthritis. Am J Vet Res 2007;68:290–296.
33. Baltzer AWA, Moser C, Jansen SA, et al. Autologous condi- tioned serum (Orthokine) is an effective treatment for knee osteoarthritis. Osteoarthritis Cartilage 2009;17:152–160.
34. Wehling P, Moser C, Frisbie D, et al. Autologous conditioned serum in the treatment of orthopedic diseases: The Orthokine® therapy. BioDrugs 2007;21:323–332.
35. Grove JE, Bruscia E, Krause DS. Plasticity of bone marrow- derived stem cells. Stem Cells 2004;22:487–500.
36. Du H, Taylor HS. Contribution of Bone Marrow-Derived Stem Cells to Endometrium and Endometriosis. Stem Cells 2007;25:2082–2086.
37. Wu DC, Boyd AS, Wood KJ. Embryonic stem cell transplan- tation: potential applicability in cell replacement therapy and regenerative medicine. Front Biosci 2007;12:4525– 4535.
38. Baker DEC, Harrison NJ, Maltby E, et al. Adaptation to cul- ture of human embryonic stem cells and oncogenesis in vivo. Nat Biotechnol 2007;25:207–215.
39. Caplan AI. Mesenchymal stem cells. J Orthop Res 1991; 9:641–650.
40. Ding DC, Shyu WC, Lin SZ. Mesenchymal stem cells. Cell Transplant 2011;20:5–14.
41. Smith RKW, Webbon PM. Harnessing the stem cell for the treatment of tendon injuries: Heralding a new dawn? Br J Sports Med 2005;39:582–584.
54 2022 / Vol. 68 / AAEP PROCEEDINGS
42. Koch TG, Betts DH. Stem cell therapy for joint problems using the horse as a clinically relevant animal model. Expert Opin Biol Ther 2007;7:1621–1626.
43. Fortier LA, Smith RK. Evidence for stem cells in cartilage regeneration. AAEP Proc 2007;53:329–334.
44. Fortier LA, Smith RKW. Regenerative medicine for tendi- nous and ligamentous injuries of sport horses. Vet Clin North Am Equine Pract 2008;24:191–201.
45. Mambelli LI, Winter GHZ, Kerkis A, et al. A novel strategy of mesenchymal stem cells delivery in the uterus of mares with endometriosis. Theriogenology 2013;79:744–750.
46. Mambelli LI, Mattos RC, Winter GHZ, et al. Changes in expression pattern of selected endometrial proteins follow- ing mesenchymal stem cells infusion in mares with endome- triosis. PLoS One 2014;9:e97889.
47. Zhao J, Zhang Q, Wang Y, et al. Uterine infusion with bone marrow mesenchymal stem cells improves endometrium thickness in a rat model of thin endometrium. Reprod Sci 2015;22:181–188.
48. Kenney RM, Doig PA. Equine endometrial biopsy. In Morrow DA, ed. Current Therapy in Theriogenology. W.B. Saunders Company, Philadelphia, PA; 1986, 723-729.
49. Alvarenga MA, do Carmo MT, Segabinazzi LG, et al. Feasibility and Safety of Endometrial Injection of Auto- logous Bone Marrow Mesenchymal Stem Cells in Mares. J. Equine Vet. Sci 2016;42:12–18.
50. Carrade DD, Lame MW, Kent MS, et al. Comparative analy- sis of the immunomodulatory properties of equine adult- derived mesenchymal stem cells. Cell Med 2012;4:1–12.
51. Gugjoo MB, Amarpal, Makhdoomi DM, et al. Equine mesen- chymal stem cells: Properties, sources, characterization, and potential therapeutic applications. J. Equine Vet. Sci 2019;72:16–27.
52. da Silva Meirelles L, Fontes AM, Covas DT, et al. Mecha- nisms involved in the therapeutic properties of mesenchy- mal stem cells. Cytokine Growth Factor Rev 2009;20:419– 427.
53. Iyer SS, Rojas M. Anti-inflammatory effects of mesenchymal stem cells: Novel. Expert Opin Biol Ther 2008;8:569–582.
54. Frisbie DD, Kisiday JD, Kawcak CE, et al. Evaluation of adipose-derived stromal vascular fraction or bone marrow- derived mesenchymal stem cells for treatment of osteoar- thritis. J Orthop Res 2009;27:1675–1680.
55. Frisbie DD, Smith RKW. Clinical update on the use of mes- enchymal stem cells in equine orthopaedics. Equine Vet J 2010;42:86–89.
56. Hao P, Liang Z, Piao H, et al. Conditioned medium of human adipose-derived mesenchymal stem cells mediates protec- tion in neurons following glutamate excitotoxicity by regu- lating energy metabolism and GAP-43 expression. Metab Brain Dis 2014;29:193–205.
57. Maia L, Dias MC, Moraes CND, et al. Conditioned medium : A new alternative for cryopreservation of equine umbilical cord mesenchymal stem cells. Cell Biol Int 2017;41:239–248.
58. Pawitan JA. Prospect of stem cell conditioned medium in re- generative medicine. Biomed Res Int 2014;2014:965849– 965814.
59. Ahmadi M, Rahbarghazi R, Aslani MR, et al. Bone marrow mesenchymal stem cells and their conditioned media could potentially ameliorate ovalbumin-induced asthmatic changes. Biomed. Pharmacother 2017;85:28–40.
60. Pouya S, Heidari M, Baghaei K, et al. Study the effects of mesenchymal stem cell conditioned medium injection in mouse model of acute colitis. Int Immunopharmacol 2018; 54:86–94.
61. Lange-Consiglio A, Rossi D, Tassan S, et al. Conditioned medium from horse amniotic membrane-derived multipo- tent progenitor cells: Immunomodulatory activity in vitro and first clinical application in tendon and ligament injuries in vivo. Stem Cells Dev 2013;22:3015–3024.
62. Burnouf T, Chou M-L, Wu Y-W, et al. Antimicrobial activity of platelet (PLT)-poor plasma, PLT-rich plasma, PLT gel, and solvent/detergent-treated PLT lysate biomaterials against wound bacteria. Transfusion 2013;53:138–146.
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