MEDICINE I: DRUGS, DISEASE SURVEILLANCE, AND DISASTERS 3. Results and Discussion
When differentiating between EPM+ horses and EPM horses with other neurological diseases, the combination of serum and CSF SarcoFluor testing addedmore infor- mation to the model accuracy than either test alone. The likelihood ratio of a positive test was highest at se- rum:CSF ratio of 32. Models involving serum and CSF for phosphorylated neurofilament heavy protein did not identify cutoffs that showed statistically significant like- lihood ratios for a positive test and showed lower area under the curve.
Acknowledgments
Funding Sources This research was funded by the Center for Equine Health, School of Veterinary Medicine, University of
California-Davis, with additional contributions from public and private donors.
Declaration of Ethics
The Authors have adhered to the Principles of Veterinary Medical Ethics of theAVMA.
Conflict of Interest All Authors work for the School of Veterinary Medicine, University of California-Davis, which mar- kets the SarcoFluor for diagnostic purposes.